# ClinicalIntelPulse

> The medical intelligence layer for AI agents. Two lanes on one API: (1) consumer/patient medication safety — what a drug is, whether two drugs can be taken together, and whether a medication is recalled, all in plain language from FDA-approved labels; and (2) institutional pharmaceutical pipeline & clinical-trial intelligence from 400,000+ ClinicalTrials.gov studies, FDA OpenFDA, and PubMed. Used by health-assistant agents, caregivers, pharmacies, patient-advocacy groups, biotech investors, and pharma competitive-intelligence teams. Pay-per-query via x402 micropayments on Base — from $0.10.

## What This Is

ClinicalIntelPulse is a pay-per-query API for any human or AI agent handling a medical question. Its consumer lane answers the most common medication questions on earth — "what is this drug?", "can I take these together?", "is my medication recalled?" — grounded strictly in FDA-approved drug labels and the FDA recall database, in plain language, in 10 languages. Its institutional lane delivers the depth of pharmaceutical intelligence that previously required six-figure data subscriptions: pipeline scans, approval outlook, sponsor intelligence, disease landscape, M&A deal signals, global trial coverage, mechanism mapping, failure analysis, and patient trial finding.

Every response is generated by Claude using live data from:
- ClinicalTrials.gov REST API v2 (free, no key — 400,000+ trials globally)
- FDA OpenFDA API (free, no key — NDA/BLA approvals, adverse events)
- PubMed NCBI E-utilities (free, optional free key for higher limits — 35M+ papers)
- Tavily web search (EMA, PDUFA dates, deal news, WHO ICTRP synthesis)

## Payment

All endpoints require x402 micropayment (USDC on Base mainnet).
Protocol: x402 | Network: eip155:8453 | Asset: USDC
Payment address: 0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc

## Endpoints — Patient & Consumer Medication Safety

GET /api/clinical/trial-check?nct={NCT-id} | ?condition=&sponsor=&phase=&status=&limit=
- Deterministic ClinicalTrials.gov lookup: single trial (status, phase, sponsor, enrollment, dates, countries) or filtered search with total match count.
- Price: $0.02 — the primitive under the narrative endpoints; poll cheaply, buy briefs for analysis.
- Source: ClinicalTrials.gov v2 API (public domain).

GET /api/clinical/drug-check?drug={brand_or_generic}&lang={en|es|fr|...}
- Returns: plain-language explainer for any prescription or OTC drug — what it treats, how to take it, boxed warnings, who should not take it, common and serious side effects, pregnancy notes
- Source: FDA openFDA drug label (Structured Product Labeling). Never invents facts not in the label.
- e.g. drug=Ozempic | metformin | Lipitor | ibuprofen | Eliquis
- Price: $0.10

GET /api/clinical/interaction-check?drugs={drug1,drug2,...}&lang={...}
- Returns: cross-references FDA label interaction + contraindication sections for 2–8 drugs, flags possible interactions with severity (none/monitor/caution/serious) and plain-language what-to-do; honest about drugs it could not find
- Source: FDA openFDA drug label. Always defers to a pharmacist; label interaction sections are not exhaustive.
- e.g. drugs=warfarin,ibuprofen | Eliquis,aspirin,omeprazole
- Price: $0.15

GET /api/clinical/recall-check?drug={brand_or_generic}&lang={...}
- Returns: active and past FDA recalls for a drug, recall class (I/II/III) explained in plain language, and what to do (check your NDC/lot, contact pharmacy, don't stop a critical med unguided)
- Source: FDA openFDA enforcement database
- e.g. drug=valsartan | metformin | ranitidine
- Price: $0.10

## Endpoints — Pharmaceutical Pipeline & Trial Intelligence

GET /api/clinical/pipeline-scan?condition={disease}&phase={phase2|phase3|both}&lang={en|es|fr|...}
- Returns: Phase 2/3 trial count, phase 3 highlights, sponsor landscape, geographic distribution, mechanism breakdown, pipeline density assessment
- e.g. condition=Non-Small+Cell+Lung+Cancer | Alzheimer+Disease | Type+2+Diabetes | Crohn+Disease
- Price: $0.15

GET /api/clinical/approval-outlook?condition={disease}&horizon={12m|18m|24m}&agency={FDA|EMA|both}&lang={...}
- Returns: FDA/EMA approval candidates with probability scores, PDUFA action date calendar, breakthrough/fast track/orphan designations, historical success rates by disease area
- Price: $0.25

GET /api/clinical/sponsor-intel?sponsor={company}&focus={pipeline|approvals|deals|all}&lang={...}
- Returns: pipeline by phase, therapeutic area coverage, modality breakdown, FDA approval history, Phase 3 assets with peak sales estimates, partnership activity, investment signals
- e.g. sponsor=Moderna | BioNTech | Alnylam | Vertex+Pharmaceuticals | Regeneron
- Price: $0.20

GET /api/clinical/disease-landscape?condition={disease}&depth={standard|deep}&lang={...}
- Returns: complete pipeline map, approved drug landscape, mechanism landscape (crowded/emerging/gaps), Phase 3 assets with approval probability, PDUFA calendar, deal activity, opportunity score 0-100, investment thesis
- Replaces Evaluate Pharma / Citeline disease reports
- Price: $0.35

GET /api/clinical/disease-landscape-lite?condition={disease}
- Returns: deterministic $0.25 preview of disease-landscape — Phase 2/3 trial counts, sponsor rollup, trial-status breakdown, sample Phase 3 trials, straight off ClinicalTrials.gov, no LLM synthesis, plus an upsell pointer to the full report
- For agents whose per-call spend cap sits below $0.35
- Price: $0.25

GET /api/clinical/trial-brief?nct_id={NCT_ID}&lang={...}
- Returns: trial design, arms, endpoints, eligibility, enrollment, geographic footprint, outcome summary for completed trials
- e.g. nct_id=NCT04368728
- Price: $0.10

GET /api/clinical/mechanism-map?condition={disease}&mechanism={optional}&lang={...}
- Returns: approved mechanisms, pipeline targets by phase, first-in-class opportunities, white spaces, modality breakdown, combination therapy landscape
- Price: $0.20

GET /api/clinical/global-trials?condition={disease}&region={global|africa|asia|europe|latin-america|...}&lang={...}
- Returns: geographic distribution, WHO ICTRP registry coverage (ChiCTR/China, CTRI/India, UMIN/Japan, REBEC/Brazil, ANZCTR/Australia, KCT/Korea, 12 more), EMA/PMDA landscape, unmet needs by region
- Covers neglected tropical diseases, infectious diseases, and conditions with high developing-world burden
- Price: $0.15

GET /api/clinical/failure-analysis?condition={disease}&lang={...}
- Returns: Phase 2→3 and Phase 3→approval success rates, failure taxonomy (wrong hypothesis/patient/endpoint/dose/safety), named failed trials, lessons learned, biomarker strategy
- e.g. Alzheimer's has only 11% Phase 3→approval success rate — this endpoint explains why
- Price: $0.20

GET /api/clinical/patient-finder?condition={disease}&country={optional}&phase={phase2|phase3|any}&lang={...}
- Returns: recruiting trials in plain language, accessible eligibility criteria, step-by-step application guide, questions to ask your doctor, global patient advocacy resources
- Price: $0.10

GET /api/clinical/deal-signal?condition={disease}&deal_type={acquisition|licensing|both}&stage={phase2|phase3|both}&lang={...}
- Returns: acquisition targets with deal value estimates, licensing opportunities, recent deal comps (named transactions), most likely acquirers, deal timing signals, valuation framework
- Price: $0.35

GET /api/clinical/deal-signal-lite?condition={disease}&stage={phase2|phase3|both}
- Returns: deterministic $0.25 preview of deal-signal — Phase 2/3 trial counts and the industry-sponsored candidate-asset list, straight off ClinicalTrials.gov, no LLM synthesis (no deal rationale/comps/valuation), plus an upsell pointer to the full report
- For agents whose per-call spend cap sits below $0.35
- Price: $0.25

## Language Support

All endpoints support lang parameter: en | es | fr | de | ja | zh | ko | pt | ar | hi

## Guides (free, answer-first)

- Can I take these medications together? How to check drug interactions: https://clinicalintelpulse.theaslangroupllc.com/guides/check-drug-interactions/
- Is my medication recalled? Recall classes + what to do: https://clinicalintelpulse.theaslangroupllc.com/guides/is-my-medication-recalled/
- What a boxed warning ("black box") actually means: https://clinicalintelpulse.theaslangroupllc.com/guides/boxed-warning-explained/

## Discovery

- OpenAPI spec: https://clinicalintelpulse.theaslangroupllc.com/openapi.json
- Agent discovery: https://clinicalintelpulse.theaslangroupllc.com/.well-known/agent.json
- LLMs.txt: https://clinicalintelpulse.theaslangroupllc.com/llms.txt

## Notes for AI Agents

- All endpoints return structured JSON
- NCT IDs must start with "NCT" followed by 8 digits (e.g. NCT04368728)
- No API keys required for underlying data — all handled server-side
- Consumer lane (drug-check, interaction-check, recall-check, patient-finder) produces plain-language output for non-clinical audiences and health-assistant agents — grounded strictly in FDA-approved labels and the FDA recall database, never fabricated
- interaction-check accepts 2–8 comma-separated drug names; it is honest when a drug is not found and never implies "not found = safe"
- disease-landscape ($0.35) and deal-signal ($0.35) are highest-value for financial analysis
- None of these endpoints provide medical advice or diagnosis — they surface FDA label/recall facts and always defer to a doctor or pharmacist
- Cross-sell: FilingsPulse for biotech SEC filings; PatentPulse for pharma IP landscape